procainamide Intravenous

proe-KANE-a-mide

Intravenous route(Solution)

The use of procainamide hydrochloride as well as other antiarrhythmic agents should be reserved for patients with life-threatening ventricular arrhythmias. The prolonged administration of procainamide often leads to the development of a positive ANA test, with or without symptoms of a lupus erythematosus-like syndrome. Agranulocytosis, bone marrow depression, neutropenia, hypoplastic anemia, and thrombocytopenia in patients receiving procainamide hydrochloride have been reported, some of which were fatal. It is recommended that complete blood counts be performed at weekly intervals for the first three months of therapy, and periodically thereafter. Discontinue procainamide if hematologic disorders are identified .

Commonly used brand name(s)

In the U.S.

• Pronestyl

Available Dosage Forms:

• Solution

Therapeutic Class: Antiarrhythmic, Group IA

Uses For procainamide

Procainamide injection is used to treat irregular heartbeats and to slow an overactive heart. When the heart has a normal heartbeat (rhythm), it will work more efficiently. Procainamide works by slowing the nerve impulses in the heart and reducing the sensitivity of heart tissues.

procainamide is available only with your doctor's prescription.

The oral dosage forms of procainamide are no longer available in the United States.

Before Using procainamide

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For procainamide, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to procainamide or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of procainamide injection in the pediatric population. Safety and efficacy have not been established.

Geriatric

No information is available on the relationship of age to the effects of procainamide injection in geriatric patients. However, elderly patients are more likely to have age-related kidney problems, which may require an adjustment in the dose for patients receiving procainamide injection.

Pregnancy

	Pregnancy Category	Explanation
All Trimesters	C	Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.

Breast Feeding

Studies in women suggest that this medication poses minimal risk to the infant when used during breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking procainamide, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using procainamide with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

• Bepridil


• Cisapride


• Dronedarone


• Grepafloxacin


• Levomethadyl


• Mesoridazine


• Pimozide


• Sparfloxacin


• Terfenadine


• Thioridazine


• Ziprasidone

Using procainamide with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Acecainide


• Ajmaline


• Alcuronium


• Alfuzosin


• Amisulpride


• Amitriptyline


• Amoxapine


• Apomorphine


• Aprindine


• Arsenic Trioxide


• Asenapine


• Astemizole


• Atracurium


• Azithromycin


• Chloral Hydrate


• Chloroquine


• Chlorpromazine


• Ciprofloxacin


• Cisatracurium


• Citalopram


• Clarithromycin


• Clomipramine


• Clozapine


• Crizotinib


• Dasatinib


• Desipramine


• Disopyramide


• Dofetilide


• Dolasetron


• Doxacurium


• Doxepin


• Droperidol


• Enflurane


• Erythromycin


• Fingolimod


• Flecainide


• Fluconazole


• Fluoxetine


• Foscarnet


• Gallamine


• Gatifloxacin


• Gemifloxacin


• Granisetron


• Halofantrine


• Haloperidol


• Halothane


• Hexafluorenium


• Hydroquinidine


• Ibutilide


• Iloperidone


• Imipramine


• Isoflurane


• Isradipine


• Lapatinib


• Levofloxacin


• Lidocaine


• Lidoflazine


• Lopinavir


• Lorcainide


• Lumefantrine


• Mefloquine


• Methadone


• Metocurine


• Mivacurium


• Moricizine


• Moxifloxacin


• Nalidixic Acid


• Norfloxacin


• Nortriptyline


• Octreotide


• Ofloxacin


• Ondansetron


• Paliperidone


• Pancuronium


• Pazopanib


• Pentamidine


• Perflutren Lipid Microsphere


• Pimozide


• Pipecuronium


• Pirmenol


• Posaconazole


• Prajmaline


• Prilocaine


• Probucol


• Procainamide


• Promethazine


• Propafenone


• Protriptyline


• Quetiapine


• Quinidine


• Quinine


• Ranolazine


• Risperidone


• Rocuronium


• Salmeterol


• Saquinavir


• Sertindole


• Sodium Phosphate


• Sodium Phosphate, Dibasic


• Sodium Phosphate, Monobasic


• Solifenacin


• Sorafenib


• Sotalol


• Spiramycin


• Succinylcholine


• Sulfamethoxazole


• Sultopride


• Sunitinib


• Telavancin


• Telithromycin


• Tetrabenazine


• Toremifene


• Trazodone


• Trifluoperazine


• Trimethoprim


• Trimipramine


• Tubocurarine


• Vandetanib


• Vardenafil


• Vasopressin


• Vecuronium


• Vemurafenib


• Voriconazole


• Ziprasidone


• Zolmitriptan


• Zotepine

Using procainamide with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Amiodarone


• Cimetidine

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of procainamide. Make sure you tell your doctor if you have any other medical problems, especially:

• Heart block or


• Heart rhythm problem (e.g., QT prolongation) or


• Lupus erythematosus, history of—Should not use in patients with these conditions.

• Heart failure, congestive or


• Myasthenia gravis—May make these conditions worse.

• Kidney disease or


• Liver disease—Use with caution. The effects may be increased because of slower removal from the body.

Proper Use of procainamide

A nurse or other trained health professional will give you procainamide in a hospital. procainamide is given through a needle placed in one of your veins.

Your doctor will only give you a few doses of procainamide until your condition improves, and then you may be switched to an oral medicine that works the same way. If you have any concerns about this, talk to your doctor.

Precautions While Using procainamide

It is important that your doctor check your progress carefully while you are receiving procainamide to make sure it is working properly. This will allow necessary changes in the amount of medicine you receive and may also help reduce side effects.

Dizziness or lightheadedness may occur with procainamide, especially in elderly patients and when large doses are used. Patients should use extra care to avoid falling. Make sure you know how you react to procainamide before you drive, use machines, or do anything else that could be dangerous if you are dizzy or not alert.

procainamide Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

Less common

• Fever and chills


• joint pain or swelling


• pains with breathing


• skin rash or itching

Rare

• Bleeding, blistering, burning, coldness, discoloration of skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, or warmth at the injection site


• Confusion


• fever or sore mouth, gums, or throat


• hallucinations (seeing, hearing, or feeling things that are not there)


• mental depression


• unusual bleeding or bruising


• unusual tiredness or weakness

Get emergency help immediately if any of the following symptoms of overdose occur:

Symptoms of overdose

• Decrease in urination


• dizziness (severe) or fainting


• drowsiness


• fast or irregular heartbeat


• nausea and vomiting

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

• Diarrhea


• hardening or thickening of the skin where the needle is placed


• loss of appetite

Less common

• Dizziness or lightheadedness

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See also: procainamide Intravenous side effects (in more detail)

The information contained in the Thomson Reuters Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.

The use of the Thomson Reuters Healthcare products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Thomson Reuters Healthcare and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, THOMSON REUTERS HEALTHCARE MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Thomson Reuters Healthcare does not assume any responsibility or risk for your use of the Thomson Reuters Healthcare products.

More procainamide Intravenous resources

• Procainamide Intravenous Side Effects (in more detail)
• Procainamide Intravenous Use in Pregnancy & Breastfeeding
• Drug Images
• Procainamide Intravenous Drug Interactions
• Procainamide Intravenous Support Group
• 0 Reviews for Procainamide Intravenous - Add your own review/rating

Compare procainamide Intravenous with other medications

• Arrhythmia

Lidocaine Hydrochloride Injection BP 2% w / v (Goldshield plc)

1. Name Of The Medicinal Product

Lidocaine Hydrochloride Injection BP 2% w/v.

2. Qualitative And Quantitative Composition

Each 1ml of solution contains 20mg of Lidocaine Hydrochloride.

3. Pharmaceutical Form

Solution for injection.

4. Clinical Particulars

4.1 Therapeutic Indications

Lidocaine is a local anaesthetic of the amide group. Lidocaine Hydrochloride Injection BP is for use in infiltration anaesthesia, intravenous regional anaesthesia and nerve blocks.

4.2 Posology And Method Of Administration

The method of administration of lidocaine varies according to the procedure (infiltration anaesthesia, intravenous regional anaesthesia or nerve block).

The dosage should be adjusted according to the response of the patient and the site of administration. The lowest concentration and smallest dose producing the required effect should be given.

The maximum dose for healthy adults should not exceed 200 mg [or 500mg if given in solutions containing adrenaline (epinephrine)].

Children and elderly or debilitated patients require smaller doses, commensurate with age & physical status.

4.3 Contraindications

Known hypersensitivity to anaesthetics of the amide type; hypovolemia; complete heart block.

Solutions containing adrenaline (epinephrine) should not be used in areas of the body supplied by end arteries or otherwise having a compromised blood supply such as digits, nose, ear or penis. Solutions containing adrenaline (epinephrine) should not be given intravenously.

4.4 Special Warnings And Precautions For Use

As with other local anaesthetics, lidocaine should be used with caution in patients with epilepsy, cardiac conduction disturbances, congestive cardiac failure, bradycardia or impaired respiratory function, if the dose or site of administration is likely to produce high blood levels. Lidocaine is metabolised in the liver and it should be used with caution in patients with impaired hepatic function.

Facilities for resuscitation should be available when administering local anaesthetics.

The effect of local anaesthetics may be reduced if the injection is made into an inflamed or infected area.

Solutions containing adrenaline (epinephrine) should be used with caution in patients with hypertension, cardiac disease, cerebrovascular insufficiency, thyrotoxicosis, in patients taking tricyclic antidepressants, MAOI's or receiving potent anaesthetic agents.

Lidocaine is considered to be unsafe in patients with porphyria because it has shown to be porphyrogenic in animals.

4.5 Interaction With Other Medicinal Products And Other Forms Of Interaction

The speed of onset and duration of action of lidocaine are increased by the addition of a vasoconstrictor such as adrenaline (epinephrine) and absorption from the site of injection is reduced.

Dopamine and 5-hydroxytryptamine depletion both reduce the convulsant threshold of lidocaine, and the concomitant use of pethidine increases the incidence of lidocaine-induced convulsions in animals.

Cimetidine and propranolol depress microsomal enzyme activity, thus enhancing lidocaine toxicity during anti-arrhythmic infusions if concomitantly administered with these drugs.

The use of prenylamine in the prophylaxis of angina contra-indicates the use of lidocaine for arrhythmia since this combination may precipitate A-V block and ventricular tachycardia.

The cardiac depressant effects of lidocaine are additive with those of beta-blockers, and of other antiarrhythmics.

Hypokalemia produced by acetazolamide, loop diuretics, and thiazides antagonizes the effect of lidocaine.

There is increased risk of ventricular arrhythmias when lidocaine is given with quinupristin/dalfopristin - avoid concomitant use.

Neuromuscular blockade may be enhanced and prolonged when lidocaine is given with suxamethonium.

4.6 Pregnancy And Lactation

Although animal studies have revealed no evidence of harm to the foetus, lidocaine should not be administered during early pregnancy unless the benefits are considered to outweigh the risks.

Small amounts of lidocaine are secreted into breast milk and the possibility of an allergic reaction in the infant, albeit remote, should be borne in mind when using lidocaine in nursing mothers.

4.7 Effects On Ability To Drive And Use Machines

Where outpatient anaesthesia affects areas of the body involved in driving or operating machinery, patients should be advised to avoid these activities until normal function is fully restored.

4.8 Undesirable Effects

In common with other local anaesthetics, adverse reactions to lidocaine are rare and are usually the result of raised plasma concentrations due to accidental intravascular injection, excessive dosage or rapid absorption from highly vascular areas, or may result from a hypersensitivity, idiosyncrasy or diminished tolerance on the part of the patient. Systemic toxicity mainly involves the central nervous system and/or the cardiovascular system.

CNS reactions may be excitatory and/or depressant and may manifest as nervousness, tremor, blurred vision, nausea and vomiting, followed by drowsiness, coma and possibly respiratory arrest. The excitatory reactions may be brief or may not occur at all, so that the first signs of toxicity may be drowsiness, followed by coma and respiratory failure. Cardiovascular reactions are depressant and may manifest as hypotension, bradycardia, myocardial depression and possibly cardiac arrest.

Allergic reactions are rare. They may be characterised by cutaneous lesions, urticaria, oedema or anaphylactoid reactions. Skin testing for allergy to lidocaine is not considered to be reliable.

4.9 Overdose

The effects of overdosage involve the CNS, where reactions may be excitatory and/or depressant, and the CVS where the effects are depressant. In the event of an overdose, immediate steps should be taken to maintain the circulation and respiration and to control convulsions.

A patent airway should be established and oxygen should be administered, together with assisted ventilation if necessary. The circulation should be maintained with infusions of plasma or intravenous fluids. Where further supportive treatment of circulatory depression is required, use of a vasopressor agent may be considered although this involves a risk of CNS excitation. Convulsions may be controlled by the intravenous administration of diazepam or thiopental sodium, bearing in mind that anti-convulsant drugs may also depress respiration and the circulation. If cardiac arrest should occur, standard cardiopulmonary resuscitation procedures should be instituted.

Dialysis is of negligible value in the treatment of acute overdosage with lidocaine.

5. Pharmacological Properties

5.1 Pharmacodynamic Properties

Lidocaine is a local anaesthetic of the amide type. It is used to provide local anaesthesia at various sites in the body and it acts by inhibiting the ionic refluxes required for the initiation and conduction of impulses, thereby stabilising the neuronal membrane. In addition to blocking conduction in nerve axons in the peripheral nervous system, lidocaine has important effects on the central nervous system and cardiovascular system. After absorption, lidocaine may cause stimulation of the CNS followed by depression and in the cardiovascular system, it acts primarily on the myocardium where it may produce decreases in electrical excitability, conduction rate and force of contraction.

5.2 Pharmacokinetic Properties

Lidocaine is absorbed from injection sites including muscle and its rate of absorption is determined by factors such as the site of administration and the tissue vascularity. Except for intravascular administration, the highest blood levels occur following intercostal nerve block and the lowest after subcutaneous administration. Lidocaine is bound to plasma proteins, including alpha-1-acid-glycoprotein. The drug crosses the blood-brain and placental barriers.

Lidocaine is metabolised in the liver and about 90% of a given dose undergoes N-dealkylation to form monoethylglycinexylidide and glycinexylidide, both of which may contribute to the therapeutic and toxic effects of lidocaine. Further metabolism occurs and metabolites are excreted in the urine with less than 10% as unchanged lidocaine. The elimination half-life of lidocaine following an intravenous bolus injection is one to two hours, but this may be prolonged in patients with hepatic dysfunction.

5.3 Preclinical Safety Data

No further relevant information other than that which is included in other sections of the Summary of Product Characteristics.

6. Pharmaceutical Particulars

6.1 List Of Excipients

Sodium Chloride

Sodium Hydroxide

Hydrochloric Acid

Water for Injections

6.2 Incompatibilities

Lidocaine caused precipitation of amphotericin, methohexital sodium and sulfadiazine sodium in glucose injection. It is recommended that admixtures of lidocaine and glyceryltrinitrate should be avoided.

6.3 Shelf Life

3 years (36 months).

6.4 Special Precautions For Storage

Do not store above 25ºC.

6.5 Nature And Contents Of Container

2ml, 5ml, 10ml & 20ml translucent plastic ampoules, polypropylene Ph. Eur., packed in cardboard cartons to contain 10, 20, 50 and 100 ampoules.

6.6 Special Precautions For Disposal And Other Handling

If only part used, discard the remaining solution.

Administrative Data

7. Marketing Authorisation Holder

Antigen International Ltd

Roscrea

Co. Tipperary

Ireland

8. Marketing Authorisation Number(S)

PL 02848/0177

9. Date Of First Authorisation/Renewal Of The Authorisation

22/03/2006

10. Date Of Revision Of The Text

22/03/2006

Genapap Drops

Pronunciation: a-seet-a-MIN-oh-fen
Generic Name: Acetaminophen
Brand Name: Examples include Tempra 1 and Genapap

Genapap Drops are used for:

Treating minor aches and pains due to headache, muscle aches, backache, arthritis, the common cold, flu, toothache, menstrual cramps, and immunizations, and for temporarily reducing fever.

Genapap Drops are an analgesic and antipyretic (fever reducer). It works by lowering a chemical in the brain that stimulates pain nerves and the heat-regulating center in the brain.

Do NOT use Genapap Drops if:

• you are allergic to any ingredient in Genapap Drops

Contact your doctor or health care provider right away if any of these apply to you.

Before using Genapap Drops:

Some medical conditions may interact with Genapap Drops. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding


• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement


• if you have allergies to medicines, foods, or other substances


• if you have a history of alcohol abuse or you drink 3 or more alcohol-containing drinks every day


• if you have liver or kidney problems, hepatitis, or phenylketonuria (PKU)

Some MEDICINES MAY INTERACT with Genapap Drops. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Anticoagulants (eg, warfarin) because the risk of their side effects, including bleeding, may be increased by Genapap Drops


• Isoniazid because the risk of liver problems may be increased

This may not be a complete list of all interactions that may occur. Ask your health care provider if Genapap Drops may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Genapap Drops:

Use Genapap Drops as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Take Genapap Drops by mouth with or without food.


• Use the dropper that comes with Genapap Drops to measure your dose. Ask your pharmacist for help if you are unsure of how to measure your dose.


• Replace original bottle cap to maintain child resistance.


• If you miss a dose of Genapap Drops and you are taking it regularly, take it as soon as possible. If several hours have passed or if it is nearing time for the next dose, do not double the dose to catch up, unless advised by your health care provider. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Genapap Drops.

Important safety information:

• Genapap Drops has acetaminophen in it. Before you start any new medicine, check the label to see if it has acetaminophen in it too. If it does or if you are not sure, check with your doctor or pharmacist.


• Genapap Drops may harm your liver. Your risk may be greater if you drink alcohol while you are using Genapap Drops. Talk to your doctor before you take Genapap Drops or other fever reducers if you drink more than 3 drinks with alcohol per day.


• Severe or persistent sore throat or sore throat accompanied by high fever, headache, nausea, and vomiting may be serious. Consult a doctor promptly. Do not use for more than 2 days or give to children younger than 3 years old unless directed by a doctor.


• Genapap Drops may cause the results of some in-home test kits for blood cholesterol to be wrong. Check with your doctor or pharmacist if you are taking Genapap Drops and need to check your blood cholesterol at home.


• For pain and fever in ADULTS: Stop use of Genapap Drops and ask your doctor if pain gets worse or lasts more than 10 days, fever gets worse or lasts more than 3 days, or new symptoms occur or redness or swelling is present.


• For pain and fever in CHILDREN: Stop use and ask a doctor if fever gets worse or lasts more than 3 days, pain gets worse or lasts more than 5 days, or redness or swelling is present or any new symptoms appear.


• Different brands of Genapap Drops may have different dosing instructions for CHILDREN. Follow the dosing instructions on the package labeling. If your doctor has given you instructions, follow those. If you are unsure of the dose to give a child, check with your doctor or pharmacist.


• PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Genapap Drops while you are pregnant. Genapap Drops are found in breast milk. If you are or will be breast-feeding while you use Genapap Drops, check with your doctor. Discuss any possible risks to your baby.

Possible side effects of Genapap Drops:

All medicines may cause side effects, but many people have no, or minor, side effects. When used in small doses, no COMMON side effects have been reported with this product. Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); dark urine or pale stools; unusual fatigue; yellowing of the skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

See also: Genapap side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include dark urine; excessive sweating; extreme fatigue; nausea and vomiting; stomach pain.

Proper storage of Genapap Drops:

Store Genapap Drops at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Genapap Drops out of the reach of children and away from pets.

General information:

• If you have any questions about Genapap Drops, please talk with your doctor, pharmacist, or other health care provider.


• Genapap Drops are to be used only by the patient for whom it is prescribed. Do not share it with other people.


• If your symptoms do not improve or if they become worse, check with your doctor.


• Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Genapap Drops. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

More Genapap resources

• Genapap Side Effects (in more detail)
• Genapap Use in Pregnancy & Breastfeeding
• Genapap Drug Interactions
• Genapap Support Group
• 0 Reviews for Genapap - Add your own review/rating

Compare Genapap with other medications

• Fever
• Muscle Pain
• Pain
• Sciatica

Tepox Cal

Tepox Cal may be available in the countries listed below.

Ingredient matches for Tepox Cal

Calcium Pidolate

Calcium Pidolate is reported as an ingredient of Tepox Cal in the following countries:

• Spain

International Drug Name Search

Loratadina Induquimica

Loratadina Induquimica may be available in the countries listed below.

Ingredient matches for Loratadina Induquimica

Loratadine

Loratadine is reported as an ingredient of Loratadina Induquimica in the following countries:

• Peru

International Drug Name Search

Therevac S.B.

Ingredient matches for Therevac S.B.

Docusate

Docusate Sodium is reported as an ingredient of Therevac S.B. in the following countries:

• United States

International Drug Name Search

Cenestin

Pronunciation: CON-ju-gate-ed ESS-tro-jenz
Generic Name: Conjugated Estrogens (Synthetic A)
Brand Name: Cenestin

Cenestin increases the chances of getting cancer of the uterus. Report any unusual vaginal bleeding right away while using Cenestin. Vaginal bleeding after menopause may be a warning sign of cancer of the uterus (womb). Your health care provider should check any unusual vaginal bleeding to find out the cause.

Do not use Cenestin with or without progestins (eg, medroxyprogesterone) to prevent heart disease, heart attacks, strokes, or dementia. Using estrogens with or without progestins may increase your chances of getting heart attacks, strokes, breast cancer, and blood clots. Using estrogens, with or without progestins, may increase your risk of dementia, based on a study of women 65 years of age or older. You and your health care provider should talk regularly about whether you still need treatment with Cenestin.

Cenestin is used for:

Treating a variety of symptoms due to menopause (hot flashes, vaginal itching, burning, dryness). It may also be used for other conditions as determined by your doctor.

Cenestin is a mixture of estrogen hormones. It works by replacing natural estrogens in a woman who can no longer produce enough estrogen.

Do NOT use Cenestin if:

• you are allergic to any ingredient in Cenestin


• you are pregnant or suspect you may be pregnant


• you have known, suspected, or a history of breast cancer (unless directed by your doctor) or other cancers that are estrogen-dependent


• you have abnormal vaginal bleeding of unknown cause


• you have impaired liver function or liver disease, or the blood disease porphyria


• you have recently (within the last year) had a stroke or heart attack


• you have blood clots or circulation disorders

Contact your doctor or health care provider right away if any of these apply to you.

Before using Cenestin:

Some medical conditions may interact with Cenestin. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are planning to become pregnant or are breast-feeding


• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement


• if you have allergies to medicines, foods, or other substances


• if you have an abnormal mammogram


• if you have asthma (wheezing), a benign breast nodule, bone cancer, depression, diabetes, endometriosis or endometrial (uterine) cancer, epilepsy (seizures), gallbladder disease, heart problems, high blood pressure, kidney problems, liver problems or a history of yellowing of the skin or eyes, lupus, migraines, obesity, pancreatitis, uterine fibroids, thyroid problems or have high calcium levels in your blood


• if you use tobacco, you are going to have surgery, or you will be on bed rest


• if you have a family history of high cholesterol, lipid, calcium, or triglyceride levels; or breast cancer

Some MEDICINES MAY INTERACT with Cenestin. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Hydantoins (eg, phenytoin) and rifampin because they may decrease Cenestin's effectiveness

This may not be a complete list of all interactions that may occur. Ask your health care provider if Cenestin may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Cenestin:

Use Cenestin as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• An extra patient leaflet is available with Cenestin. Talk to your pharmacist if you have questions about this information.


• Take Cenestin by mouth with food or immediately after a meal to prevent stomach upset.


• Take Cenestin at the same time each day.


• Discuss with your doctor stopping Cenestin 4 to 6 weeks before surgery.


• If you miss a dose of Cenestin, take it as soon as possible. If it is almost time for the next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Cenestin.

Important safety information:

• Cenestin may cause dizziness. These effects may be worse if you take it with alcohol or certain medicines. Use Cenestin with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.


• Smoking while taking Cenestin may increase your risk of blood clots (especially in women older than 35 years of age).


• Before using Cenestin, you will need to have a complete medical and family history exam, which will include blood pressure, breast, stomach, and pelvic organ exams and a Pap smear.


• You should have periodic mammograms as determined by your doctor. Follow your doctor's instructions for examining your own breasts, and report any lumps immediately.


• Your doctor should reevaluate you every 3 to 6 months to determine whether or not you need to continue taking Cenestin.


• If you are only being treated for vaginal menopause symptoms, products applied locally such as vaginal creams, tablets, or rings should be considered before products taken by mouth or absorbed through the skin. If you have other medical conditions and are prescribed estrogens for more than one condition, consult your doctor about your treatment plan and its options.


• Non-drug therapy to help prevent bone loss includes a weight-bearing exercise plan, as well as adequate daily calcium and vitamin D intake. Consult your doctor of pharmacist for more details.


• Diabetes patients - Cenestin may affect your blood sugar. Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine.


• Cenestin may cause dark skin patches on your face (melasma). Exposure to the sun may make these patches darker, and you may need to avoid prolonged sun exposure and sunlamps. Consult your doctor regarding the use of sunscreens and protective clothing.


• If you wear contact lenses and you develop problems with them, contact your doctor.


• If you will be having surgery or will be confined to a chair or bed for a long period of time (eg, a long plane flight), notify your doctor beforehand. Special precautions may need to be taken in these circumstances while you are taking Cenestin.


• Cenestin may interfere with certain lab tests. Be sure your doctor and lab personnel know you are using Cenestin.


• Lab tests, including a lipid profile, may be performed while you use Cenestin. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.


• Cenestin should be used with extreme caution in CHILDREN; safety and effectiveness in children have not been confirmed.


• Cenestin may affect growth in CHILDREN. They may need regular growth checks while they use Cenestin.


• PREGNANCY and BREAST-FEEDING: Do not use Cenestin if you are pregnant. Avoid becoming pregnant while you are taking it. If you think you may be pregnant, contact your doctor right away. Cenestin is found in breast milk. If you are or will be breast-feeding while you use Cenestin, check with your doctor. Discuss any possible risks to your baby..

Possible side effects of Cenestin:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Back pain; bloating; breast pain; depression; diarrhea; dizziness; flu syndrome; gas; hair loss; headache; increased cough; increased/decreased interest in sex; indigestion; infection; irregular vaginal bleeding or spotting; itching; joint pain; lightheadedness; leg cramps; muscle aches; nausea; nervousness; pain; runny nose; sinus inflammation; sleeplessness; sore throat; stomach pain; upper respiratory tract infection; vaginal inflammation; weakness; weight changes.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); abnormal bleeding from the vagina; breast lumps; changes in vision or speech; chest pain; dizziness; fainting; mental/mood changes; pain or tenderness in the upper abdomen; pain in the calves; severe headache; sudden shortness of breath; swelling of the hands or feet; unusual vaginal discharge/itching/odor; vomiting; weakness or numbness of an arm or leg; yellowing of the skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

See also: Cenestin side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include excessive vaginal bleeding 2 to 7 days following overdose; nausea and vomiting.

Proper storage of Cenestin:

Store Cenestin at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Cenestin out of the reach of children and away from pets.

General information:

• If you have any questions about Cenestin, please talk with your doctor, pharmacist, or other health care provider.


• Cenestin is to be used only by the patient for whom it is prescribed. Do not share it with other people.


• If your symptoms do not improve or if they become worse, check with your doctor.


• Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Cenestin. Additionally, your doctor may have prescribed Cenestin for a use not mentioned above. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

More Cenestin resources

• Cenestin Side Effects (in more detail)
• Cenestin Dosage
• Cenestin Use in Pregnancy & Breastfeeding
• Drug Images
• Cenestin Drug Interactions
• Cenestin Support Group
• 2 Reviews for Cenestin - Add your own review/rating

• Cenestin Prescribing Information (FDA)


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